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Mysimba vs Wegovy: The Key Differences

Professor Franklin Joseph
Professor Joseph, an expert in diabetes and obesity management, leads clinical trials, chairs the Western Cheshire Diabetes Network, and priorities person-centered care for optimal outcomes.

Mysimba and Wegovy can both help you lose weight – but what are the differences between the two? Do they work in a similar way, or are they completely different? Let’s find out. 

Read on to learn all about Wegovy and Mysimba, and the key differences between the two. 

What is Mysimba?

Mysimba is a weight loss treatment – and unlike many others on the market at the moment (such as Wegovy and Mounjaro), Mysimba comes in tablet form. You take this tablet once a day before moving up to two doses of two tablets a day. This makes Mysimba a good option if you don’t like needles. 

Mysimba contains two main ingredients: 

  • Naltrexone hydrochloride
  • Bupropion hydrochloride

These two ingredients target areas of the brain that control hunger signals and feelings of fullness – helping you to control food cravings and reduce your appetite. This is how you lose weight by taking Mysimba.

What is Wegovy? 

Wegovy is a once-weekly injection. It contains semaglutide – a GLP-1 receptor agonist that helps you to regulate your appetite and food intake. 

It suppresses your appetite and makes you feel fuller for longer. This makes it much easier to maintain the calorie deficit needed to lose weight safely and effectively. 

When you take Wegovy, you'll begin at 0.25mg - and gradually increase until you reach the maximum maintenance dose of 2.4mg a week. Many people start losing weight on Wegovy by 12 weeks and many even earlier.

Mounjaro

GIP & GLP-1 Medication

Prices start from:

£205.00

£129.00/month

£76 off when you sign-up to our newsletter
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Lose up to 20% in the first year
Cancel anytime
Dose escalation available
Start Assessment

Mounjaro

GIP & GLP-1 Medication

Prices start from:

£205.00

£129.00/month

£76 off when you sign-up to our newsletter
Free Shipping
Lose up to 15% in the first year
Cancel anytime
Dose escalation available
Start Assessment
Key Differences Between Mysimba and Wegovy

The Key Differences Between Mysimba and Wegovy

Criteria Mysimba Wegovy
Active Ingredient Naltrexone and Bupropion Semaglutide
Administration Oral tablets Once-weekly injection
Cost £109 – £200 for 5 weeks £200 - £300+ per month
Availability Readily available in the UK Limited availability in the UK
Effectiveness Moderately effective – average weight loss of 8.1%. Learn more More effective – average weight loss of 14.9% (STEP 1 trial). Learn more
Time to See Results May notice results within 4-8 weeks but most people see results after 12 weeks of treatment Patients may lose at least 6% of their body weight by 12 weeks and then 10% by 20 weeks. Learn more
Eligibility BMI of 30+, or a BMI of 27-30 with a weight-related health complication BMI of 30+ or 27-30 with a weight-related health issue (lower BMI thresholds for certain ethnic backgrounds)
How it Works Suppresses appetite and cravings, affecting areas of the brain that control food intake, energy, and pleasure Mimics GLP-1 hormone to reduce cravings and appetite and slow down digestion so you feel fuller for longer

 

Which is More Effective for Weight Loss?

Wegovy is the most effective option for weight loss. Here’s why:

  • In the STEP-1 trial, patients taking 2.4mg of Wegovy had an average weight loss of over 14.9% over 68 weeks. Learn more
  • Almost 50% achieved around 15% weight loss, and 85% lost around 5%.
  • The average weight loss over 4 years was 10%.

You can expect to lose up to 15% of your body weight when taking Wegovy. The average weight loss on Mysimba is 3.7% to 5.7%. Learn more

  • Patients lost an average of 8.1% of their body weight
  • 30% achieved >10% weight loss
  • 46% lost >5% weight loss

To summarise, Wegovy appears to be much more effective for weight loss than Mysimba. Learn all of Wegovy’s benefits here.

 

Which is Best for Me?

Choosing the right option can be tough. If you’re exploring your weight loss treatment options, our team of weight loss experts at Dr Frank’s Weight Loss Clinic are on hand to help.

  • If you’re looking for a more effective option, then Wegovy may be the best choice for you. However, if you hate needles, then you may prefer Mysimba.
  • If you’d prefer a once-weekly option, then Wegovy may be the best choice. However, if you’d prefer to take a tablet every day, then you might prefer Mysimba.
  • If you're looking for a cheaper option, Mysimba might be more suitable, costing around £115 per month. Wegovy can cost up to £300 per month (on the highest dose).

Both are great options if you have a BMI of 30+ or 27+ (depending on health issues). However, Wegovy is generally the more attractive option for sustained weight loss. Learn more here.

We have GLP-1 medications available – including Wegovy – to help you lose weight but also support people who wish to try Mysimba. We offer a personalised approach and can determine the best course of treatment for you, considering your goals, medical history, and preferences.

Make the most of our monthly reviews and well-being calls. We can ensure you're on the right track and help you overcome any obstacles that may get in your way.

Begin your weight loss journey with Dr Frank's Weight Loss Clinic or complete an online assessment today.

Continue Your Weight Loss Discovery

Uncover More Strategies and Success Stories on Our Blog

How Much Does Mounjaro Cost in the UK?
Read More
Can You Get NHS Weight Loss Injections?
Read More
How Long Does Wegovy Take To Work?
Read More

Real People, Real Results

Susan lost 5 Stone in just 12 months

“For the first time, losing weight has been both easy and successful in my life.”

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Dimitra lost 4 Stone in just 8 months

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Lauren lost 5 Stone in just 8 months

“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”

Susan lost 5 Stone in just 12 months

“For the first time, losing weight has been both easy and successful in my life.”

Cadi lost 3 Stone in just 12 months

“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”

Ethan lost 5 Stone in just 5 months

“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”

Dimitra lost 4 Stone in just 8 months

“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”

Lauren lost 5 Stone in just 8 months

“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”

Susan lost 5 Stone in just 12 months

“For the first time, losing weight has been both easy and successful in my life.”

Cadi lost 3 Stone in just 12 months

“If you're aiming to lose weight or manage polycystic ovaries, go for this program. It's undoubtedly the best decision.”

Ethan lost 5 Stone in just 5 months

“I’ve never felt so comfortable in my own skin. It's a newfound sense of confidence and well-being that has positively impacted every aspect of my life.”

Dimitra lost 4 Stone in just 8 months

“I cannot recommend this programme enough; it truly works! It's the sole solution that has been effective after my long struggle.”

Lauren lost 5 Stone in just 8 months

“I would advise anyone considering this programme that it's a transformative experience. It has allowed me to embrace life and fully enjoy my twenties.”